Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.

ABSTRACT:

Objectives

A systematic review was conducted to explore the immunogenicity of biologic agents across inflammatory diseases and its potential impact on efficacy/safety.

Methods

Literature searches were conducted through November 2016 to identify controlled and observational studies of biologics/biosimilars administered for treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis (nr-axSpA), psoriasis (Ps), Crohn's disease, and ulcerative colitis.

Results

Of >21,000 screened publications, 443 were included. Anti-drug antibody (ADAb) rates varied widely among biologics across diseases (and are not directly comparable because of immunoassay heterogeneity);

SUBMITTER: Strand V 

PROVIDER: S-EPMC5548814 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature