Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer worldwide and liver metastases are the leading cause of death in patients with CRC. In this study, we performed next-generation sequencing profiling on primary colorectal tumor tissues obtained from three CRC patients with liver metastases and three CRC patients without liver metastases to identify differentially expressed genes (DEGs) that might be responsible for the metastases process. After filtering 2690 DEGs, comprising 996 upregulated and 1694 downregulated RNAs, 22 upregulated and 73 downregulated DEGs were identified. Gene ontology (GO) and pathway analyses were performed to determine the underlying mechanisms. Single-organism process (biological process), cell (cellular component), and binding (molecular function) were the m

SUBMITTER: Wang S 

PROVIDER: S-EPMC5548889 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature