Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability.

ABSTRACT:

Rationale

Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability.

Objectives

The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abuse liability comparator products (usual brand combustible cigarettes and nicotine gum, respectively) in a group of 45 EC-naïve smokers.

Methods

Enrolled subjects' ratings of subjective effects and nicotine uptake over 6 h were used to measure abuse liability and pharmacokinetics following in-clinic use of each EC.

Results

Use of Vuse Solo resulted in subjective measures and nicotine uptake that were between those of combustible cigarettes and nicoti

SUBMITTER: Stiles MF 

PROVIDER: S-EPMC5548902 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature