GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer.

ABSTRACT:

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Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense stroma consisting of a prevalence of activated fibroblasts whose functional contributions to pancreatic tumorigenesis remain incompletely understood. In this study, we provide the first identification and characterization of mesenchymal stem cells (MSC) within the human PDA microenvironment, highlighting the heterogeneity of the fibroblast population. Primary patient PDA samples and low-passage human pancreatic cancer-associated fibroblast cultures were found to contain a unique population of cancer-associated MSCs (CA-MSC). CA-MSCs markedly enhanced the growth, invasion, and metastatic potential of PDA cancer cells. CA-MSCs secreted the cytokine GM-CSF that was required for tumor cell proliferation, inva

SUBMITTER: Waghray M 

PROVIDER: S-EPMC5549011 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature