The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer.

ABSTRACT: Accumulating evidence has revealed that aberrantly expressed long non-coding transcripts are involved in the development and progression of colorectal cancer (CRC). Small nucleolar RNA host gene 3 (SNHG3) is a newly identified lncRNA, and little is known about its clinical significance and biological functions in the development of CRC. In the present study, we found that the expression of SNHG3 was significantly upregulated in CRC, and upregulation of SNHG3 predicted poor prognosis for patients with CRC as determined through analysis of the data obtained from TCGA database. Gain-of function and loss-of function assays revealed that SNHG3 markedly promoted cellular proliferation of CRC cells. Gene Set Enrichment Analysis (GSEA) suggested that high expression of SNHG3 was positively associa

SUBMITTER: Huang W 

PROVIDER: S-EPMC5549033 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature