Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis.

ABSTRACT:

Background

Preeclampsia is a multifactorial disease with unknown pathogenesis. Even when recent studies explored this disease using several bioinformatics tools, the main objective was not directed to pathogenesis. Additionally, consensus prioritization was proved to be highly efficient in the recognition of genes-disease association. However, not information is available about the consensus ability to early recognize genes directly involved in pathogenesis. Therefore our aim in this study is to apply several theoretical approaches to explore preeclampsia; specifically those genes directly involved in the pathogenesis.

Methods

We firstly evaluated the consensus between 12 prioritization strategies to early recognize pathogenic genes related to preeclampsia. A communality ana

SUBMITTER: Tejera E 

PROVIDER: S-EPMC5549357 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature