Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis.

ABSTRACT:

Background and aims

Plenty of studies were conducted to explore the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer with contradictory results. This study aims to summarize the prognostic significance of NLR in patients with ovarian cancer.

Methods

A literature search in PubMed, Cochrane Library, and Embase was conducted. The endpoints were progression-free survival (PFS) and overall survival (OS).

Results

Eleven studies involving a total of 2,892 patients were identified. The results indicated that patients with high NLR had shorter PFS compared to patients with low NLR in ovarian cancer (HR = 1.55, 95% CI = 1.15-2.08, p = 0.004, and I² = 61%). Similarly, high NLR was related to shorter OS (HR = 1.51, 95% CI

SUBMITTER: Chen S 

PROVIDER: S-EPMC5549495 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature