Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms.

ABSTRACT:

Background

Genetic polymorphisms are commonly associated with altered transcriptional activity and possibly make individuals more susceptible to periodontal disease development, increased disease severity and poor treatment outcome. The study aimed to determine the effect of Interleukin-6 (IL-6) -572 G/C (rs1800796) and IL-10 -592 C/A (rs1800872) polymorphisms on the outcomes of non-surgical periodontal therapy in a Caucasian population.

Material and methods

Sixty-eight patients with chronic periodontal disease were grouped according to their genotype: IL-6, IL-10, IL-6 and IL-10 susceptible (SCP) and non-susceptible (NSCP). All individuals were clinically evaluated at the first visit, and blood sample were collected from patients after checking the inclusion and exclusion c

SUBMITTER: Chatzopoulos GS 

PROVIDER: S-EPMC5549518 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature