Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development.

ABSTRACT: The X-linked Trap1a gene encodes the tumor rejection antigen P1A, which is expressed in fetal tissues and multiple lineages of tumor cells. The function of this gene remains unknown. Using chimeric mice with wild-type (WT) and Trap1a^-/y bone marrow, we show that Trap1a^-/y donor cells are capable of generating most lineages of hematopoietic cells, with the notable exception of T cells. Deletion of Trap1a selectively arrests T-cell development at double-negative stage 1 (DN1, with a CD4^-CD8^-CD25^-CD44⁺ phenotype). Because Trap1a is expressed in Lin^-Sca-1⁺c-Kit⁺ and common lymphoid progenitors but not in immature thymocytes (DN1-DN4), Trap1a mutations affect the differentiation potential of proge

SUBMITTER: Li CS 

PROVIDER: S-EPMC5549601 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature