One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes.

ABSTRACT: BACKGROUND:Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lewis or Brønsted acid catalyst, followed by a further reaction with metal salts to obtain the corresponding metal complexes. Very often, the yield afforded by the two-step procedure is not high, and very few oxazolinyl zinc complexes have been prepared by this route. Given that metal-oxazoline complexes often contain Lewis acidic metals, it is conceivable that the two steps may be telescoped. RESULTS:A series of novel chiral organozinc complexes 1-15 were assembled in a single step, All crystalline compounds were fully characterized, including the report of 15 X-ray crystal s

SUBMITTER: Luo M 

PROVIDER: S-EPMC5549684 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature