Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks.

ABSTRACT: Developing neuronal systems intrinsically generate coordinated spontaneous activity that propagates by involving a large number of synchronously firing neurons. In vivo, waves of spikes transiently characterize the activity of developing brain circuits and are fundamental for activity-dependent circuit formation. In vitro, coordinated spontaneous spiking activity, or network bursts (NBs), interleaved within periods of asynchronous spikes emerge during the development of 2D and 3D neuronal cultures. Several studies have investigated this type of activity and its dynamics, but how a neuronal system generates these coordinated events remains unclear. Here, we investigate at a cellular level the generation of network bursts in spontaneously active neuronal cultures by exploiting high-resolutio

SUBMITTER: Lonardoni D 

PROVIDER: S-EPMC5549760 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature