Functional corticostriatal connection topographies predict goal directed behaviour in humans.

ABSTRACT: Anatomical tracing studies in non-human primates have suggested that corticostriatal connectivity is topographically organized: nearby locations in striatum are connected with nearby locations in cortex. The topographic organization of corticostriatal connectivity is thought to underpin many goal-directed behaviours, but these topographies have not been completely characterised in humans and their relationship to uniquely human behaviours remains to be fully determined. Instead, the dominant approach employs parcellations that cannot model the continuous nature of the topography, nor accommodate overlapping cortical projections in the striatum. Here, we employ a different approach to studying human corticostriatal circuitry: we estimate smoothly-varying and spatially overlapping 'connectio

SUBMITTER: Marquand AF 

PROVIDER: S-EPMC5549843 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature