Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder.

ABSTRACT:

Background

Prior work suggests that adult bipolar disorder (BD) is associated with increased oxidative stress and inflammation. This exploratory study examined markers of lipid and protein oxidation and inflammation in adolescents with and at varying risk for BD type I (BD-I).

Methods

Blood was obtained from four groups of adolescents (9-20 years of age): (1) healthy comparison subjects with no personal or family history of psychiatric disorders (n=13), (2) subjects with no psychiatric diagnosis and at least one parent with BD-I ('high-risk', n=15), (3) subjects with at least one parent with BD-I and a diagnosis of depressive disorder not-otherwise-specified ('ultra-high-risk', n=20), and (4) first-episode patients exhibiting mixed or manic symptoms that received a diagnosis

SUBMITTER: Scola G 

PROVIDER: S-EPMC5549852 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature