Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.

ABSTRACT:

Objective

To identify and measure recently described chemical mediators, termed specialized pro-resolving mediators that actively regulate the resolution of acute-inflammation, and correlate measurements with clinical outcomes.

Design

Herein, deidentified plasma was collected from sepsis patients (n = 22 subjects) within 48 hours of admission to the ICU and on days 3 and 7 thereafter and subjected to lipid mediator profiling.

Setting

Brigham and Women's Hospital Medical Intensive Care Unit.

Subjects

Patients in the medical ICU with sepsis.

Measurements and main results

In all patients, we identified more than 30 bioactive mediators and pathway markers in peripheral blood using established criteria for arachidonic acid, eicosapentaenoic acid, and docosahe

SUBMITTER: Dalli J 

PROVIDER: S-EPMC5549882 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature