Modeling miRNA-mRNA interactions that cause phenotypic abnormality in breast cancer patients.

ABSTRACT:

Background

The dysregulation of microRNAs (miRNAs) alters expression level of pro-oncogenic or tumor suppressive mRNAs in breast cancer, and in the long run, causes multiple biological abnormalities. Identification of such interactions of miRNA-mRNA requires integrative analysis of miRNA-mRNA expression profile data. However, current approaches have limitations to consider the regulatory relationship between miRNAs and mRNAs and to implicate the relationship with phenotypic abnormality and cancer pathogenesis.

Methodology/findings

We modeled causal relationships between genomic expression and clinical data using a Bayesian Network (BN), with the goal of discovering miRNA-mRNA interactions that are associated with cancer pathogenesis. The Multiple Beam Search (MBS) algorithm

SUBMITTER: Lee S 

PROVIDER: S-EPMC5549916 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature