Association between a variation in the phosphodiesterase 4D gene and bone mineral density.

ABSTRACT:

Background

Fragility fractures caused by osteoporosis are a major cause of morbidity and mortality in aging populations. Bone mineral density (BMD) is a useful surrogate marker for risk of fracture and is a highly heritable trait. The genetic variants underlying this genetic contribution are largely unknown.

Methods

We performed a large-scale association study investigating more than 25,000 single nucleotide polymorphisms (SNPs) located within 16,000 genes. Allele frequencies were estimated in contrasting DNA pools from white females selected for low (<0.87 g/cm2, n = 319) and high (> 1.11 g/cm2, n = 321) BMD at the lumbar spine. Significant findings were verified in two additional sample collections.

Results

Based on allele frequency differences between DNA pools and

SUBMITTER: Reneland RH 

PROVIDER: S-EPMC554993 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature