Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.

ABSTRACT: Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges and often suffer from low statistical power due to multiple test correction. Here, we present a novel, alternative strategy for mapping epistasis: instead of directly identifying individual pairwise or higher-order interactions, we focus on mapping variants that have non-zero marginal epistatic effects-the combined pairwise interaction effects between a given variant and all other variants. By testi

SUBMITTER: Crawford L 

PROVIDER: S-EPMC5550000 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature