Pregnancy among cystic fibrosis women in the era of CFTR modulators.

ABSTRACT:

Background

Little is known about how new therapies that partially correct the basic cystic fibrosis (CF) defect (ivacaftor and lumacaftor) might alter hormonal contraceptive effectiveness, impact pregnancy outcomes, or affect pregnancy timing. Examination of pregnancy rates among CF women during periods of CFTR modulator therapy initiation will provide foundation for further research in this area.

Methods

The Cystic Fibrosis Foundation Patient Registry was used to examine pregnancy rates and outcomes by genotype class before, during, and after the introduction of CFTR modulator therapies between 2005 and 2014.

Results

Among women with CF, ages 15-44years, there was a slight downward trend in annual pregnancy rates from 2005 to 2014 (2% reduction per year, p=0.041). Am

SUBMITTER: Heltshe SL 

PROVIDER: S-EPMC5550358 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature