Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations.

ABSTRACT: Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer, though the population of patients who would benefit from targeting this pathway has yet to be identified. In human colorectal cancers, PIK3CA mutations most commonly occur concomitantly with loss of adenomatous polyposis coli (APC). Here, treatment strategies are investigated that target the PI3K pathway in colon cancers with mutations in APC and PIK3CA Colorectal cancer spheroids with Apc and Pi

SUBMITTER: Foley TM 

PROVIDER: S-EPMC5550373 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature