A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies.

ABSTRACT: Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-generated mutational signatures depends upon the numbers of variants available for analysis. In this work, we sought to assess whether data from well-controlled mouse models can compensate for scarce human data for some cancer types. High quality sequencing data from radiotherapy-induced cancers is particularly scarce and the mutational processes defining ionizing radiation (IR)-induced mutagenesis in vivo are poorly defined. Here, we combine sequencing data from mouse models of IR-induced malignancies and human IR-induced malignancies. To

SUBMITTER: Davidson PR 

PROVIDER: S-EPMC5550450 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature