IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration.

ABSTRACT: During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood. In neurons in culture we showed that IGF-1 receptor activation is important for growth cone assembly and axonal formation. However, the possible roles of the insulin like growth factor-1 receptor (IGF-1R) on neuronal differentiation and polarization in vivo in mammals have not yet been studied. Using in utero electroporation, we show here that the IGF-1R is essential for neocortical development. Neurons electroporated with a shRNA targeting IGF-1 receptor failed to migrate to the upper cortical layers and accumulated at the ventricular/subventricular zones. Co-electroporation with a

SUBMITTER: Nieto Guil AF 

PROVIDER: S-EPMC5550468 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature