P75^NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa.

ABSTRACT: ProNGF signaling through p75^NTR has been associated with neurodegenerative disorders. Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies that causes progressive photoreceptor cell degeneration and death, at a rate dependent on the genetic mutation. There are more than 300 mutations causing RP, and this is a challenge to therapy. Our study was designed to explore a common mechanism for p75^NTR in the progression of RP, and assess its potential value as a therapeutic target. The proNGF/p75^NTR system is present in the dystrophic retina of the rd10 RP mouse model. Compared with wild-type (WT) retina, the levels of unprocessed proNGF were increased in the rd10 retina at early degenerative stages, before the peak of photoreceptor cell dea

SUBMITTER: Platon-Corchado M 

PROVIDER: S-EPMC5550853 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature