Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.

ABSTRACT: Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.

SUBMITTER: Jung B 

PROVIDER: S-EPMC5550896 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature