Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism.

ABSTRACT:

Background

Statins are a class of therapeutics used to regulate serum cholesterol and reduce the risk of heart disease. Although statins are highly effective in removing cholesterol from the blood, their consumption has been linked to potential adverse effects in some individuals. The most common events associated with statin intolerance are myopathy and increased risk of developing type 2 diabetes mellitus. However, the pathological mechanism through which statins cause these adverse effects is not well understood.

Results

Using a murine model, we describe for the first time profound changes in the microbial composition of the gut following statin treatment. This remodelling affected the diversity and metabolic profile of the gut microbiota and was associated with reduced p

SUBMITTER: Caparros-Martin JA 

PROVIDER: S-EPMC5550934 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature