Mapping of leptin and its syntenic genes to chicken chromosome 1p.

ABSTRACT:

Background

Misidentification of the chicken leptin gene has hampered research of leptin signaling in this species for almost two decades. Recently, the genuine leptin gene with a GC-rich (~70%) repetitive-sequence content was identified in the chicken genome but without indicating its genomic position. This suggests that such GC-rich sequences are difficult to sequence and therefore substantial regions are missing from the current chicken genome assembly.

Results

A radiation hybrid panel of chicken-hamster Wg3hCl2 cells was used to map the genome location of the chicken leptin gene. Contrary to our expectations, based on comparative genome mapping and sequence characteristics, the chicken leptin was not located on a microchromosome, which are known to contain GC-rich and rep

SUBMITTER: Seroussi E 

PROVIDER: S-EPMC5550943 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature