Dynamic disorder in simple enzymatic reactions induces stochastic amplification of substrate.

ABSTRACT: A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit fluctuations in their catalytic activity, which are associated with conformational changes on a broad range of timescales. The experimental study of this phenomenon, termed dynamic disorder, has become possible thanks to advances in single-molecule enzymology measurement techniques, through which the catalytic activity of individual enzyme molecules can be tracked in time. The biological role and importance of these fluctuations in a system with a small number of enzymes, such as a living cell, have only recently started being explored. In this work, we examine a simple stochastic reaction system consisting of an inflowing substrate and an enzyme with a randomly fluctuating catalytic reactio

SUBMITTER: Gupta A 

PROVIDER: S-EPMC5550977 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature