Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.

ABSTRACT:

Background

Fusobacterium nucleatum is a gram-negative anaerobic species residing in the oral cavity and implicated in several inflammatory processes in the human body. Although F. nucleatum abundance is increased in inflammatory bowel disease subjects and is prevalent in colorectal cancer patients, the causal role of the bacterium in gastrointestinal disorders and the mechanistic details of host cell functions subversion are not fully understood.

Results

We devised a computational strategy to identify putative secreted F. nucleatum proteins (FusoSecretome) and to infer their interactions with human proteins based on the presence of host molecular mimicry elements. FusoSecretome proteins share similar features with known bacterial virulence factors thereby highlighting their

SUBMITTER: Zanzoni A 

PROVIDER: S-EPMC5551000 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature