CXCL9, a promising biomarker in the diagnosis of chronic Q fever.

ABSTRACT:

Background

In the aftermath of the largest Q fever outbreak in the world, diagnosing the potentially lethal complication chronic Q fever remains challenging. PCR, Coxiella burnetii IgG phase I antibodies, CRP and ¹⁸F-FDG-PET/CT scan are used for diagnosis and monitoring in clinical practice. We aimed to identify and test biomarkers in order to improve discriminative power of the diagnostic tests and monitoring of chronic Q fever.

Methods

We performed a transcriptome analysis on C. burnetii stimulated PBMCs of 4 healthy controls and 6 chronic Q fever patients and identified genes that were most differentially expressed. The gene products were determined using Luminex technology in whole blood samples stimulated with heat-killed C. burnetii and serum samples from ch

SUBMITTER: Jansen AFM 

PROVIDER: S-EPMC5551022 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature