MicroRNA-196 Regulates HOX Gene Expression in Human Gluteal Adipose Tissue.

ABSTRACT:

Objective

Lower body fat is associated with diminishing cardiometabolic risk. Physiological differences between gluteofemoral and abdominal subcutaneous adipocyte functions are known, but the molecular basis for depot differences in adipocyte function is poorly understood. The objective of this study was to identify depot differences in microRNA (miRNA) expression in human abdominal and gluteofemoral subcutaneous adipose tissues and their implication in gene regulation.

Methods

Abdominal and gluteofemoral adipose tissue aspirates obtained from 18 participants (9 male and 9 female, age 30 ± 1.5 y, BMI 27.3 ± 1.23 kg/m² ) were analyzed for miRNA expression profiles by next-generation DNA sequencing. The raw reads were mapped to miRBase 17, and differentially express

SUBMITTER: Divoux A 

PROVIDER: S-EPMC5551414 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature