A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging.

ABSTRACT: Here, we describe a novel polymer platform suitable for efficient diagnostics and potential theranostics based on ⁸⁹Zr-labeled N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymer conjugates. A set of polymers differing in molecular weight with either low dispersity or high dispersity were designed and synthesized and their biodistribution in vivo was successfully and precisely observed over 72 h. Moreover, the feasibility of two imaging techniques, fluorescence imaging (FI) and positron emission tomography (PET), was compared using labeled polymer conjugates. Both methods gave comparable results thus showing the enhanced diagnostic potential of the prepared polymer-dye or polymer-chelator-⁸⁹Zr constructs. The in vivo and ex vivo PET/FI studies indicated that the

SUBMITTER: Koziolova E 

PROVIDER: S-EPMC5551419 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature