Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes.

ABSTRACT: The sodium/potassium ATPase (NKA) is essential for establishing the normal intracellular [Na⁺] and [K⁺] and transmembrane gradients that are essential for many cellular functions, including cardiac electrophysiology and contractility. Different NKA isoforms exhibit differential expression levels, cellular localization, and function in different tissues and species. Prior work has indicated that the NKA-α1 isoform is quantitatively predominant in cardiac myocytes, but that the α2 isoform is preferentially concentrated in the transverse tubules (TT), possibly at junctions with the sarcoplasmic reticulum (SR) where α2 may preferentially modulate cardiac contractility. Here we measured subcellular localization of NKA-α1 and α2 using super-resolution microscopy (STED and S

SUBMITTER: Yuen GK 

PROVIDER: S-EPMC5551422 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature