A malaria vaccine protects <i>Aotus</i> monkeys against virulent <i>Plasmodium falciparum</i> infection.

ABSTRACT: The Plasmodium falciparum protein, apical membrane antigen 1 forms a complex with another parasite protein, rhoptry neck protein 2, to initiate junction formation with the erythrocyte and is essential for merozoite invasion during the blood stage of infection. Consequently, apical membrane antigen 1 has been a target of vaccine development but vaccination with apical membrane antigen 1 alone in controlled human malaria infections failed to protect and showed limited efficacy in field trials. Here we show that vaccination with AMA1-RON2L complex in Freund's adjuvant protects Aotus monkeys against a virulent Plasmodium falciparum infection. Vaccination with AMA1 alone gave only partial protection, delaying infection in one of eight animals. However, the AMA1-RON2L comple

SUBMITTER: Srinivasan P 

PROVIDER: S-EPMC5551459 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature