Ontology highlight
ABSTRACT:
SUBMITTER: Lomakin IB
PROVIDER: S-EPMC5551485 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cell reports 20170701 3
The repertoire of the density-regulated protein (DENR) and the malignant T cell-amplified sequence 1 (MCT-1/MCTS1) oncoprotein was recently expanded to include translational control of a specific set of cancer-related mRNAs. DENR and MCT-1 form the heterodimer, which binds to the ribosome and operates at both translation initiation and reinitiation steps, though by a mechanism that is yet unclear. Here, we determined the crystal structure of the human small ribosomal subunit in complex with DENR ...[more]