Expression of Autophagy-Related Proteins in Hurthle Cell Neoplasm Is Different from That in Follicular Neoplasm.

ABSTRACT:

Purpose

We aimed to evaluate expression of autophagy-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and assess the clinical implications.

Methods

265 FNs (112 follicular carcinomas and 153 follicular adenomas) and 108 HCNs (27 Hürthle cell carcinomas and 81 Hürthle cell adenomas) were made into a tissue microarray. Immunohistochemical staining and Western blot for autophagy-related proteins (beclin-1, light chain (LC) 3A, LC3B, p62, and BNIP3) were performed, and the results were statistically analyzed.

Results

A higher expression rate of beclin-1, LC3B, p62, and BNIP3 was found in HCN than in FN (P < 0.001). The expression rate of beclin-1, LC3B, p62, and BNIP3 was the highest in HCCs followed by HCAs, FCs, and FAs in that order (

SUBMITTER: Cha YJ 

PROVIDER: S-EPMC5551561 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature