Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension.

ABSTRACT:

Aims

As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH.

Methods and results

Right ventricular free wall longitudinal strain (FWLS) and LV global circumferential strain (CS) were measured at baseline, 12 weeks, and 24 weeks in 68 patients with advanced PAH randomized to imatinib or placebo in the Imatinib in Pulmonary arterial hypertension, a Randomized Efficacy Study (IMPRES) trial, and compared with 30 healthy controls. Compared with controls, PAH was associated with impaired RV FWLS (-15.9 ± 5.4 vs. -30.8 ± 4.3, respectively; P < 0.0001) a

SUBMITTER: Querejeta Roca G 

PROVIDER: S-EPMC5551563 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature