Ontology highlight
ABSTRACT:
SUBMITTER: Lyons O
PROVIDER: S-EPMC5551565 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170801 8
Venous valves (VVs) prevent venous hypertension and ulceration. We report that FOXC2 and GJC2 mutations are associated with reduced VV number and length. In mice, early VV formation is marked by elongation and reorientation ("organization") of Prox1hi endothelial cells by postnatal day 0. The expression of the transcription factors Foxc2 and Nfatc1 and the gap junction proteins Gjc2, Gja1, and Gja4 were temporospatially regulated during this process. Foxc2 and Nfatc1 were coexpressed at P0, and ...[more]