Ontology highlight
ABSTRACT:
SUBMITTER: Khalaj M
PROVIDER: S-EPMC5551568 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170801 8
The microRNA-99 (miR-99) family comprises a group of broadly conserved microRNAs that are highly expressed in hematopoietic stem cells (HSCs) and acute myeloid leukemia stem cells (LSCs) compared with their differentiated progeny. Herein, we show that miR-99 regulates self-renewal in both HSCs and LSCs. miR-99 maintains HSC long-term reconstitution activity by inhibiting differentiation and cell cycle entry. Moreover, miR-99 inhibition induced LSC differentiation and depletion in an MLL-AF9-driv ...[more]