Ontology highlight
ABSTRACT:
SUBMITTER: Machuca-Parra AI
PROVIDER: S-EPMC5551569 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170711 8
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in <i>NOTCH3</i> No therapies are available for this condition. Loss of mural cells, which encompass pericytes and vascular smooth muscle cells, is a hallmark of CADASIL and other SVDs, including diabetic retinopathy, resulting in vascular instability. ...[more]