Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.

ABSTRACT: Covering: up to 2017.Natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. A subset of natural products is produced by nonribosomal peptide synthetases (NRPSs), a family of large, modular enzymes that function in an assembly line fashion. Because of the pharmaceutical activity of many NRPS products, much effort has gone into the exploration of their biosynthetic pathways and the diverse products they make. Many interesting NRPS pathways have been identified and characterized from both terrestrial and marine bacterial sources. Recently, several NRPS pathways in human commensal bacterial species have been identified th

SUBMITTER: Gulick AM 

PROVIDER: S-EPMC5551671 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature