Ontology highlight
ABSTRACT:
SUBMITTER: Renault-Mihara F
PROVIDER: S-EPMC5551705 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
The Journal of cell biology 20170622 8
Understanding how the transcription factor signal transducer and activator of transcription-3 (STAT3) controls glial scar formation may have important clinical implications. We show that astrocytic STAT3 is associated with greater amounts of secreted MMP2, a crucial protease in scar formation. Moreover, we report that STAT3 inhibits the small GTPase RhoA and thereby controls actomyosin tonus, adhesion turnover, and migration of reactive astrocytes, as well as corralling of leukocytes in vitro. T ...[more]