A BCWD-resistant line of rainbow trout exhibits higher abundance of IgT⁺ B cells and heavy chain tau transcripts compared to a susceptible line following challenge with Flavobacterium psychrophilum.

ABSTRACT: Bacterial Cold Water Disease (BCWD) is a common, chronic disease in rainbow trout, and is caused by the gram-negative bacterium Flavobacterium psychrophilum (Fp). Through selective breeding, the National Center for Cool and Cold Water Aquaculture has generated a genetic line that is highly resistant to Fp challenge, designated ARS-Fp-R (or R-line), as well as a susceptible "control" line, ARS-Fp-S (S-line). In previous studies, resistance to Fp had been shown to correlate with naive animal spleen size, and further, naïve R-line trout had been shown to have a lower abundance of IgM⁺ and IgM⁺⁺ cells compared to S-line fish. Here we wished to first determine whether the abundance of IgT⁺ and/or IgT⁺⁺ cells differed between the two lines in naïve fis

SUBMITTER: Zwollo P 

PROVIDER: S-EPMC5551897 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature