IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.

ABSTRACT: Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the factors that trigger epithelial cell proliferation in this inflammatory process are incompletely understood. In this study, we demonstrate that IL-27 is rapidly and transiently produced by CD301b⁺ cells in the skin after injury. The functional role of IL-27 and CD301b⁺ cells is demonstrated by the finding that CD301b-depleted mice exhibit delayed wound closure in vivo, which could be rescued by topical IL-27 treatment. Furthermore, genetic ablation of the IL-27 receptor (Il27Ra^-/-) attenuates wound healing, suggesting an essential role for IL-27 signaling in skin regeneration in vivo. Mechanistically,

SUBMITTER: Yang B 

PROVIDER: S-EPMC5552041 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature