Analysis of Saliva Gene Expression during Head and Neck Cancer Radiotherapy: A Pilot Study.

ABSTRACT: Saliva, a biological fluid, is a promising candidate for novel approaches to prognosis, clinical diagnosis, monitoring and management of patients with both oral and systemic diseases. However, to date, saliva has not been widely investigated as a biomarker for radiation exposure. Since white blood cells are also present in saliva, it should theoretically be possible to investigate the transcriptional biomarkers of radiation exposure classically studied in whole blood. Therefore, we collected whole blood and saliva samples from eight head and neck cancer patients before the start of radiation treatment, at mid-treatment and after treatment. We then used a panel of five genes: BAX, BBC3, CDKN1A, DDB2 and MDM2, designated for assessing radiation dose in whole blood to evaluate gene expression

SUBMITTER: Lacombe J 

PROVIDER: S-EPMC5552048 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature