Risk score based on ten lncRNA-mRNA expression predicts the survival of stage II-III colorectal carcinoma.

ABSTRACT: The prognosis of colorectal carcinoma (CRC) is unstable in the stage II-III patients. Patients with early stage II CRC have a relative poor prognosis while other stage III CRC patients have a better prognosis. In our work, by utilizing the expression of lncRNAs and mRNAs measured by microarray (GSE39582), we constructed a risk score staging system with Cox multivariate regression model to predict the outcome of grade II-III CRC patients. Ten genes including two lncRNAs and eight mRNAs were used to estimate the survival of stage II-III CRC patients. The patients with high risk scores have poorer survival rate those with low risk scores, significantly. These results were further validated in another three independent datasets (GSE37892, GSE33113, and GSE17536). The relationship between clini

SUBMITTER: Diao R 

PROVIDER: S-EPMC5552098 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature