Hypercholesterolemia induced cerebral small vessel disease.

ABSTRACT:

Background

While hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear. We thus aimed to understand the detailed relationship between hypercholesterolemia and CSVD using the well described Ldlr-/- mouse model.

Methods

We used Ldlr-/- mice (n = 16) and wild-type (WT) mice (n = 15) at the age of 6 and 12 months. Ldlr-/- mice develop high plasma cholesterol levels following a high fat diet. We analyzed cerebral capillaries and arterioles for intravascular erythrocyte accumulations, thrombotic vessel occlusions, blood-brain barrier (BBB) dysfunction and microbleeds.

Results

We found a significant increase in the number of erythrocyte stases in 6 months

SUBMITTER: Kraft P 

PROVIDER: S-EPMC5552130 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature