The genetics of early-onset bipolar disorder: A systematic review.

ABSTRACT:

Background

Early-onset bipolar disorder has been associated with a significantly worse prognosis than late-onset BD and has been hypothesized to be a genetically homogenous subset of BD. A sizeable number of studies have investigated early-onset BD through linkage-analyses, candidate-gene association studies, genome-wide association studies (GWAS), and analyses of copy number variants (CNVs), but this literature has not yet been reviewed.

Methods

A systematic review was conducted using the PubMed database on articles published online before January 15, 2015 and after 1990. Separate searches were made for linkage studies, candidate gene-association studies, GWAS, and studies on CNVs.

Results

Seventy-three studies were included in our review. There is a lack of robust p

SUBMITTER: Kennedy KP 

PROVIDER: S-EPMC5552237 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature