Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis.

ABSTRACT:

Background

Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. However, some hyperuricemia patients, even gouty patients with tophi in the joints, never experience gout attack, which indicates that pathogenic pathways other than MSU participate in the secretion of IL-1β in the pathogenesis of acute gouty arthritis. The ATP-P2X7R-IL-1β axis may be one of these pathways.

Objective

This study examines the role of Adenosine triphosphate (ATP) in the pathogenesis of gout and the association of ATP receptor (P2X7R) function with single nucleotide polymorphisms and gout arthritis.

Methods

Non-synonymous single nucleotide polymorphisms (SNP) loci of P2X7R in Chinese people were scr

SUBMITTER: Tao JH 

PROVIDER: S-EPMC5552250 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature