Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice.

ABSTRACT: Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective. Unlike subcutaneous WAT, visceral WAT is resistant to adopting a protective thermogenic phenotype characterized by the accumulation of Ucp1⁺ beige/BRITE adipocytes (termed 'browning'). In this study, we investigated the physiological consequences of browning murine visceral WAT by selective genetic ablation of Zfp423, a transcriptional suppressor of the adipocyte thermogenic program. Zfp423 deletion in fetal visceral adipose precursors (Zfp423^loxP/loxP; Wt1-Cre), or adult visceral white adipose precursors (Pdgfrb^rtTA; TRE-Cre; Zfp

SUBMITTER: Hepler C 

PROVIDER: S-EPMC5552276 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature