Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2.

ABSTRACT:

Background and purpose

Trauma-induced osteonecrosis of the femoral head (TIONFH) is a major complication of femoral neck fractures. Degeneration and necrosis of subchondral bone can cause collapse, which results in hip joint dysfunction in patients. The destruction of bone metabolism homeostasis is an important factor for osteonecrosis. MicroRNAs (miRNAs) have an important role in regulating osteogenic differentiation, but the mechanisms underlying abnormal bone metabolism of TIONFH are poorly understood. In this study, we screened specific miRNAs in TIONFH by microarray and further explored the mechanism of osteogenic differentiation.

Design

Blood samples from patients with TIONFH and patients without necrosis after trauma were compared by microarray, and bone collapse of n

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5552299 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature