Oxidative coupling of sp ² and sp ³ carbon-hydrogen bonds to construct dihydrobenzofurans.

ABSTRACT: Metal-catalyzed cross-couplings provide powerful, concise, and accurate methods to construct carbon-carbon bonds from organohalides and organometallic reagents. Recent developments extended cross-couplings to reactions where one of the two partners connects with an aryl or alkyl carbon-hydrogen bond. From an economic and environmental point of view, oxidative couplings between two carbon-hydrogen bonds would be ideal. Oxidative coupling between phenyl and "inert" alkyl carbon-hydrogen bonds still awaits realization. It is very difficult to develop successful strategies for oxidative coupling of two carbon-hydrogen bonds owning different chemical properties. This article provides a solution to this challenge in a convenient preparation of dihydrobenzofurans from substituted phenyl alkyl eth

SUBMITTER: Shi JL 

PROVIDER: S-EPMC5552783 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature